Low-dose Naltrexone (LDN) is a safe, inexpensive, yet underused drug that is extremely beneficial for patients with any condition marked by immune system dysfunction.  Naltrexone has been used in 50mg doses for decades to help patients recover from addiction to alcohol, heroin, and other opiate drugs.  In 1980s, New York City physician Bernard Bihari, MD discovered that very low doses of Naltrexone had profound effects on the immune system.

He began giving patients with AIDS 1.5mg to 4.5mg of LDN at bedtime, and they had remarkable improvements. He then tried it with patients suffering from cancer and autoimmune disorders, with equally good results.  Today, LDN is recognized as a highly effective therapy for conditions ranging from cancer to autoimmune disorders to autism.

How Does LDN Work?

Naltrexone in small amounts works by boosting levels of endorphins. Endorphins are peptides produced in the brain and adrenal glands that are best known for relieving pain and enhancing sense of well-being—they’re responsible for the “runner’s high” brought on by strenuous exercise.  But these natural peptides are also powerful modulators of the immune system.

When LDN is taken at bedtime, it attaches to opioid receptors and temporarily blocks endorphins from attaching.  This signals the body to increase production of endorphins, which help orchestrate the activity of stem cells, macrophages, natural killer cells, T and B cells, and other immune cells.  As a result, LDN enhances the body’s ability to fight disease.

Conditions That Benefit From LDN

  • ALS (Lou Gehrig’s disease)
  • Alzheimer’s disease
  • Ankylosing spondylitis
  • Autism
  • Celiac disease
  • Chronic fatigue syndrome
  • Crohn’s disease
  • Emphysema (COPD)
  • Endometriosis
  • Fibromyalgia
  • Inflammatory bowel disease
  • Lupus
  • Multiple sclerosis (MS)
  • Parkinson’s disease
  • Psoriasis
  • Rheumatoid arthritis
  • Sarcoidosis
  • Scleroderma
  • Ulcerative colitis

Types of Cancer Treated with LDN:

  • Bladder
  • Breast
  • Colorectal
  • Glioblastoma
  • Liver
  • Lung (non-small cell)
  • Lymphocytic leukemia
  • Lymphoma
  • Malignant melanoma
  • Multiple myeloma
  • Neuroblastoma
  • Ovarian
  • Pancreatic
  • Prostate
  • Renal cell carcinoma
  • Throat
  • Uterine

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